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The global prevalence of 537 million affected in the age group of 2079 years in 2021 will rise to 783 million in 2045, with the lowest increase in incidence in Europe (13%) and the highest in the African countries south of the Sahara (134%) (1)

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The article reflects information available as of June 2026 - a point in time when the compounded GLP-1 telehealth market is active and competitive, FDA enforcement discretion policy on compounded semaglutide and tirzepatide is subject to ongoing regulatory guidance, and the broader clinical evidence base for GLP-1 receptor agonists continues to expand through newly published long-term follow-up studies

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The resulting increase in vagal toe inhibits gastric emptying and gastric acid secretion, subsequently resulting in a delay of gastric emptying, and reduction of glucose absorption (Shaefer et al, 2015)

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